Bioprospecting of fungi with antiproliferative activity from the mangrove sediment of the Tampamachoco coastal lagoon, Veracruz, Mexico


  • Homero Lumbreras Martínez Inbioteca, Universidad Veracruzana
  • César Espinoza LATEX, Universidad Veracruzana
  • José J. Fernández Instituto Universitario de Bio-Orgánica ‘‘Antonio González’’, Universidad de La Laguna, La Laguna, España
  • Manuel Norte Instituto Universitario de Bio-Orgánica ‘‘Antonio González’’, Universidad de La Laguna, La Laguna, España
  • Irene Lagunes LATEX, Universidad Veracruzana
  • José M. Padrón Instituto Universitario de Bio-Orgánica ‘‘Antonio González’’, Universidad de La Laguna, La Laguna, España
  • Jorge López-Portillo Instituto de Ecología, AC, Xalapa, Veracruz
  • Ángel Trigos LATEX, Universidad Veracruzana


Palabras clave:

bioprospecting, fungi microscopic, mangrove soils, salinity levels, anti-proliferative effect


Background: Fungi from mangrove forests represent a great potential for the bioprospecting of new bioactive metabolites. The rhizosphere of several regions of the world has been widely studied, however, there are no studies on the biodiversity of Mexican mangroves.

Objectives: To evaluate the anti-proliferative activity of fungal extracts isolated from accumulated sediments in the rhizosphere of three mangrove species distributed in three zones with different degrees of salinity in Mexico.

Methods: The isolated fungi were identified at genus level by taxonomic keys. The anti-proliferative activity was determined by the SRB assay and the strains with values of GI50 <100 μg.mL-1 were identified molecularly.

Results and conclusions: Six extracts from four strains exhibited GI50 values < 100 µg.mL-1 in at least one cancer cell line. A strain of Aspergillus pulverulentus isolated from a disturbed area of Avicennia germinans showed the highest anti-proliferative activity against six different cancer cell lines.  The GI50 values ranged from 40 to 83 µg.mL-1 in biomass extracts and 6 to 28 µg.mL-1 in culture broth extracts. This paper is the first study of bioprospecting fungi showing anti-proliferative activity in mangrove sediments in Mexico.


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Cómo citar

Lumbreras Martínez, H., Espinoza, C., Fernández, J. J., Norte, M., Lagunes, I., Padrón, J. M., … Trigos, Ángel. (2018). Bioprospecting of fungi with antiproliferative activity from the mangrove sediment of the Tampamachoco coastal lagoon, Veracruz, Mexico. Scientia Fungorum, 48, 53–60.



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