Study of the mannose/ fucose receptor on the phagocytosis of Histoplasma capsulatum yeasts
DOI:
https://doi.org/10.33885/sf.1989.3.754Abstract
Information concerning the receptors participation in the phagocytosis of
Histoplasma capsulatum fungus is scarce . The present paper is focussed on the
2~1
role of mannose/fucose murine macrophages receptors in the ~ - capsulatum yeast
_phagocytosis . T\;o types of assays were used, one blocking mannose/fucose receptors
with ligands , such as D(+) mannose or methyl-n-D-mannopyranoside, and another
by receptors overtaking a semi sol id-phase of B 1 4 4-D-polymannuronic acid . The
phagocytosis of ~ - capsulatum, in the presence of blocked ligands, showed a smaller
percentage than controls (20.5%) and values of 11 .5 and 7.5% were obtained by
using D(+) mannose and methyl-n-D-mannopyranoside, respectively . Differences between
controls and both ligands values were significant (p<0 .005). Results with
Candida albicans, used as a reference microorganism, showed a 23% of phagocytosis
with D(+) mannose and 31% with methyl-n-D-mannopyranoside, whereas 38% with controls
. The receptors overtaking assays showed a difference (p<0 .02) bet11een the
phagocytosis of ~· capsulatum controls (40.5%) and those obtained in the presence
of s 1-> 4-D-polymannuronic acid (29.5%), whereas no difference 11as obtained when
c . albicans was used. Generally, c. albicans developed a higher percentage of
phagocytosis than ~ · capsulatum. -The phagocytosis index for both microorganisms
11as similar in the two types of assays used, and most macrophages phagocytized 1
to 2 yeasts, followed by 3 to 6, and very f ew macrophages phagocytized more than 6 .
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