Resistance abrogation to murine histoplasmosis induced by antibody
DOI:
https://doi.org/10.33885/sf.1986.3.656Abstract
The course of humoral and cellular responses were followed throughout
infection in experimental histoplasmosis. A possible modulatory role of immune
sera in the cell-mediated immune response, developed during the infection
produced by Histoplasma capsulatum, was also studied. The results demonstrated
that there was a cyclic distribution of cellular and humoral immune responses in
¡nfected mice and that the passive transfer of anti-Histoplasma antibodies
abrogated the survival of mice sublethally ¡nfected, when the sera were transferred
3 h prior to infection. The results obtained from this experimental model suggest that antibody may play a modulating role ¡n cell-mediated responsos in
histoplasmosis.
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