Refining risk assessment of Ochratoxin A through applicable toxicological experimentation
DOI:
https://doi.org/10.33885/sf.2004.3.928Keywords:
ochratoxin A, carcinogenicity, genotoxicity, DNA adducts, risk assessmentAbstract
Ochratoxin A is primarily a nephrotoxin in many animal species but it is also a renal
carcinogen in aging rats given the compound over many months. Potential carcinogenicity is the
principal consideration in risk assessment for human exposure in food. Whether or not the
mycotoxin is itself genotoxic by binding to DNA is an important factor in determining acceptable
contamination of foodstuffs. A current European research programme seeks to clarify the question
14 14 of genotoxicity through detection of any C found bound to renal DNA of rats given C ochratoxin
A of high specific radioactivity. This approach is complemented by study of gene expression
changes in rat kidney during chronic exposure to a tumourogenic regime of ochratoxin A, thereby
pointing positively to active toxicologic influences leading to the carcinomas.
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